Our
goals are to:
- design, construct and characterize a batch Nanonozzle Sandwich Electroporation (NSE) and a continuous Converging Flow Electroporation (CFE) platform; and
- characterize in vitro transfection efficiency and uptake for selected ONs and genes for cancer and stem cells.
Items (a) and (b) support the Drug/Gene Delivery Testbed and the Cell-based
Devices and Constructs Testbed.
Related Research Briefs (.pdf) :
- Targeted Delivery of Anti-Sense Oligonucleotides for Leukemia Therapy Using Immunolipopolyplex (ILP)
- Nanoparticles Synthesized by Microfluidic Hydrodynamic Focusing (MHF) Devices for Gene Delivery Into Embryonic Stem Cells and Leukemia Cells
- Liposomal Encapsulation of Flavopiridol for the Treatment of Chronic Lymphocytic Leukemia
- miRNA Delivery to Leukemia Cells Through TfR-Targeted Liposomes
- Nanoparticles for Drug and Gene Delivery via Electrohydrodynamic Spraying
- Cell Patch and Membrane Sandwich Electroporation
- Continuous Flow Electroporation
- Elucidating the Fate of Polymer-DNA Nanoparticles in Oral Gene Delivery
